I-17-OH-progesterone (i-17-hydroxyprogesterone, i-17-OGG, i-17-oh-progesterone) iyisandulela samahomoni; uhlobo oluthi "umkhiqizo ophelile", lapho amahomoni ahlukahlukene (i-cortisol, estradiol, i-testosterone) eyenziwa ngenqubo eyinkimbinkimbi yokuguqulwa kwamagciwane.
Izimbangela zokwanda kwe-17-OH-progesterone
Isizathu sezinga elikhuphuka lika-17-oh-progesterone livame ukutholakala ezigulini ezinama-adrenal noma ama-ovari. Ukukhubazeka kwama-acrenal cortex (PDCN) okubangelwa yi-congenital iyona imbangela evame kakhulu yokwanda okunjalo. Ukungasebenzi komzimba kuhlobene nokuntuleka noma ukungabi nalutho lwe-enzyme ethi 21-hydroxylase, okuyinto, kanye ne-17-OH-progesterone, ehilelekile ekuqaliseni i-hormone cortisol. I-enzyme ayitholakali noma ingekho ngemali encane, okwamanje njengoba i-precursor ye-hormone 17-OH-progesterone ikhiqizwa ngokweqile kuze kube ngaphezu kokujwayelekile.
Kunezinhlobo ezimbili ze-VDKN: eziyingqayizivele nezingajwayelekile. I-VDKN ye-Classical inqunywa ezinsukwini zokuqala / izinyanga zokuphila kwengane ngempawu zangaphandle zomtholampilo we-hermaphroditism yamanga. Ukuze uhlolisise uhlobo oluhlukile lwe-VDKN, njengombuso, kungenzeka kuphela kumfana (ngokumelene nesimo sangemuva: i-hirsutism, i-acne, i-acne, ukungalingani komjikelezo wesimiso) noma eminyakeni yobudala (lapho abesifazane bebhekene nezinkinga zokukhulelwa nokubeletha).
Ngaphezu kwalokho, ukuhlolwa kwegazi ekunqumeni izinga le-17-OH-progesterone kungabonisa ukuthi kukhona okungaphezu kokujwayelekile uma:
- i-polycystic i-ovary syndrome (i-PCOS);
- i-androgen-okhiqiza izicubu zama-ovari noma izigulane eziyingozi;
- ukugula noma isifo sika-Itenko-Cushing;
- i-hypothalamic syndrome;
- i-hyperprolactinemia ;
- nezinye izifo.
Amanani we-normative ka-17-OH-progesterone
Izindlela ze-hormone zobulili, ikakhulukazi ezazisungulela i-17-OH-progesterone, zingase zihluke ema-laboratories ahlukene okuxilonga. Ekuxilongweni kufanele kuqondiswe izinkomba zokubhekisela zebhoritri ethile, ngokuvamile kuboniswa emiphumela yokuhlaziywa.
Odokotela abagunyazayo bavame ukukholelwa ukuthi izinga eliphakeme eliphakeme lika-17-OH-progesterone kumfazi onempilo ongeyena okhulelwe aludinga ukwelashwa futhi lihlukile kwendabuko. Umkhawulo walokhu kwanda ngu-5 nmol / L = 150 ng / dl = 1.5 ng / l.
Abesifazane abakhulelwe abenzi ukuhlolwa kwegazi ngo-17-OH-progesterone, ngesikhathi sokukhulelwa, izinga le-17-GPG liyanda, leli qiniso lingumkhuba wokuphila. Futhi lapho kungenakuqhathaniswa ngokuphelele ukubeka ukwelashwa ezingeni eliphakeme lika-17-OH-progesterone ngesikhathi sokukhulelwa. Okuwukuphela kokukodwa kukhona amacala we-VDKN yakudala.
Indlela yokunciphisa 17-OH-progesterone?
Uma, ngokusho kwemiphumela yokuhlolwa, izinga le-17-OH-progesterone landa, kubaluleke kakhulu ukuqonda izimbangela zokuphulwa ngaphambi kokuqala ukwelashwa. Ukwelashwa "okuyimpumputhe," eyenziwa inamba enkulu odokotela, ukuthembela ezindinganisweni zokudala zokwelapha, akuyikuxazulula le nkinga, kodwa kuyayikwanda kakhulu.
Ngakho-ke, kanjani ukunciphisa izinga lika-17-OH-progesterone? Kungakhathaliseki ukuthi yini eyabangela ukwanda, owesifazane umiselwe ukusetshenziswa kwesikhathi eside se-COC - ukuhlanganiswa kokubeletha komlomo (Jess, Yarin, Diana-3 noma abanye). Ngakho-ke, uma owesifazane ethola ukuthi unesimo se-PCOS, ngokusebenza ngendlela evamile yezinhlayiya ze-COC eyodwa ngaphambi kokukhulelwa kuhlelwe, ngokuvamile kuvame.
Uma imbangela yezinga eliphakanyisiwe le-17-OCG liyi-VDKN engeyona i-classic, ukuhlolwa okuphelele kwe-endocrinologist kanye ne-genetics kuyadingeka,
Ukuphakama kwe-17-OH-progesterone kuningi lamacala kuyingozi yokungasebenzi. I-Dexamethasone, i-prednisolone noma enye i-glucocorticosteroids kufanele ithathwe kuphela uma kwenzeka i-PDCA engaqinisekisiwe engekho emthethweni futhi ihlinzeke kuphela ukuthi ukukhulelwa akukwenzekanga ngaphezu konyaka owodwa, futhi zonke ezinye izimbangela zokungabikho kwemvelo zifakiwe.