I-Antimulylerov hormone eyaziwa odokotela hhayi esikhathini esidlule, kodwa ngosizo lwakhe, bafunde ukuhlonza izinkinga ezithile zesistimu yokuzala, banqume ubulili futhi babikezela nokuqala kokuya esikhathini. Ngokuvamile, ukuhlaziywa kwe-AMG kunqunywe umjozi wezifo zamasosha-endocrinologist esiteji sokuqala sokwelapha ukungabi nabantwana ngosizo lwezobuchwepheshe bokuzala (i-IVF, i-insemination yokufakelwa). I-antimulylerov ephezulu i-hormone - isibonakaliso esesabekayo, ekhuluma ngokukhona kwezifo ezibi kakhulu.
I-AMG emadodeni nakwabesifazane
I-hormone ka-Antimiller (AMG) i-glycoprotein ehlobene nezici zokukhula. Lezi zinto ziqala ukuthuthukiswa phakathi nenkathi yokuthuthukiswa kwamabriyoni: kubafana abazayo - emavikini angu-7-8, nasemantombazaneni esizayo - cishe amasonto angama-32-36 okukhulelwa.Leli hormone elibhekene nokubunjwa kwesimiso sokuzala: ngaphansi kwethonya le-AMG, umbungu we-asexual une-involution (ukuguqulwa okuqhubekayo) kwemidanso yase-Mullerian - ama-rudiments wesibindi esizayo nesibhubhu esingaziwa. Ngemva kokuzalwa kwabafana emzimbeni, i-hormone iyaqhubeka ikhiqizwa ngobuningi ngamaseli aseSertoli, futhi lapho kuqala ukukhulelwa izinga le-antimulylerovoy hormone linciphile kakhulu.
Abesifazane bakwa-AMG bahlanganisa amaseli we-granulosa avela ku-trimester yesithathu yokukhulelwa ngaphambi kokuqala kokuya esikhathini. Uma kuqhathaniswa namadoda, okuqukethwe kwe-hormone ye-antimulylerovaya egazini lomzimba obuthakathaka kuncane kakhulu, futhi ngemva kokuqala kokukhulelwa, izinga le-AMH liyancipha kancane kancane. Kungani lokhu kwenzeka?
Ngokujwayelekile, wonke owesifazane obeletha unezitshalo zamaqanda, okufika kancane kancane ekufikeni kwesikhathi sokuya esikhathini. Ngesikhathi sokuya esikhathini, izintambo eziningana zikhula ngesikhathi esisodwa ku-ovary, enye yazo (ephezulu) iyoba yiqanda elivuthiwe. Esikhathini esithile sokuvuthwa kwama-germ cells, i-hormone i-antimulyler ikhiqizwa elawula ukukhula kwama-follicles. Ososayensi bathole ukuthi izinga le-AMG liqondana ngqo nenani lamaqanda angase abe khona. Ngakho, ngosizo lwe-ATM, umuntu angalinganisa isitoreji se-ovarian wesifazane futhi athole iziphetho mayelana nokuqala kokuya esikhathini.
Antimulylerov i-hormone iphakanyiswa - izizathu
Ngokuvamile izinga le-antimulylerovoy hormone emadodeni lingu-0,49-5,98 ng / ml, ngoba ubulili obuhle kakhulu lesi sibonakaliso sifana no-1-2.5 ng / ml. Yiqiniso, kunamaphutha amancane okujwayelekile. Isibonelo, kuveli ye-anti-Muller ye-hormone ye-3 ng / mg, akufanele ukhathazeke. Kodwa-ke, kwamanye ama-antimulylerov hormone akhula kakhulu: amanani we-AGM angaba ngu-5-6, kanti ngezinye izikhathi 9 ng / ml. Iyini isizathu sezinkomba ezinjalo?
Odokotela bathola ukuthi kulabafazi abasebenzisa i-hormone i-antimulylerov ngaphezu kwesijwayelekile bahlotshaniswa nokuba khona kwama-ovaries we-polycystic, kanye nesifo se-granulosa se-ovary. Ngaphezu kwalokho, i-AMG ephezulu ingase ikhombise ukuthi i-endogine (i-ovulatory) yokungasebenzi noma ukulibaziseka ekuthuthukiseni ucansi. AMG ngenhla evamile
Emadodeni, i-hormone ye-antimuller ekhulayo ikhuluma nge-cryptorchidism (indawo ye-testes ngaphandle kwe-scrotum), ukubambezeleka ekuthuthukiseni ngokocansi, amaphutha ekukhiqizweni kwe-androgens nezinye izinkinga zesistimu yokuzala.
Kodwa-ke, akuyona njalo i-AMG ephezulu ekhombisa ukutholakala kwezifo. Ngezinye izikhathi isimo sesiguli sinethonya elikhulu emiphumeleni yocwaningo: ukucindezeleka, izifo ezimbi, imidlalo enamandla ingathinta izinga le-hormone egazini. Ngakho-ke, izinsuku ezintathu ngaphambi kokuhlaziywa, kubalulekile ukuhola indlela yokuphila ethule, ugweme ukuhlukumezeka nokugwema imikhuba emibi uma kungenzeka.