I-Verapamil yidakamizwa enqunyelwe ukuvinjelwa kwesiteshi se-calcium, uma kunesidingo. Isidakamizwa iVerapamil sinemininingwane eminingi yokusetshenziswa. Ngosizo lwalo, ungaqhuba i-prophylaxis yokuhlaselwa kwe-angina, ne- Prinzmetal angina pectoris .
Isenzo sesidakamizwa se-Verapamil
Izakhiwo eziyinhloko zokwelapha zalesi sidakamizwa ngenxa yikhono layo elihle kakhulu lokungavumeli i-calcium ions ukuba ingenele amangqamuzana abhebhezelayo emasendeni futhi abe yi-cardiomyocytes. Into esebenzayo yalesi sidakamizwa inciphisa isidingo se-carbohydrate e-O2 (oksijeni), ukunciphisa ukuthengiswa kwe-myocardial nokunciphisa kwenhliziyo.
Ngaphezu kwalokho, u-verapamil uyakwazi ukwandisa imishanguzo ye-coronary, ngaleyo ndlela, yandisa ukugeleza kwegazi kwe-coronary. Ukunciphisa ithoni yemithwalo ephathekayo yezikebhe zomhlaba, i-Verapamil inomphumela omubi kakhulu. Ngama-arrhythmias angaphezulu, uveza umphumela we-antiarrhythmic, okwenza izinga lokushaya kwenhliziyo libuyele evamile.
Iyini i-Verapamil?
Lesi sidakamizwa siboniswa ukuthi:
- angina pectoris;
- i-supranventicular, i-ciliary ne- tachycardia yesinus ;
- ukucindezeleka komzimba.
Izimpawu zokusetshenziswa kwe-verapamil yinkinga ephezulu yegazi, isifo somfutho wegazi ophezulu esiyingxenyeni encane yokujikeleza kwegazi.
Futhi kufanelekile ukwelashwa nokuvimbela ama-arrhythmias ahlukahlukene aphezulu:
- i-extrasystole;
- tachycardias paroxysmal;
- i-flutter kanye ne-fibrillation ye-atrial.
Ngemuva kokungenisa, isidakamizwa sithathwe yi-90%, futhi ukutholakala kwayo kungama-20-35% uma kuqala kudlula isibindi. Ngesikhathi sokungena kwesikhathi eside futhi ekukhuleni okuphezulu, le nkhomba iyanda.
Ukusetshenziswa nokuphikisana kwe-Verapamil yezidakamizwa
Udokotela kumele anikeze irejista kanye nomthamo ngamunye. Njengomthetho, kubantu abadala, umthamo wokuqala uvela kuma-milligram angu-40 kuya kwangu-ayisishiyagalombili ngosuku. Umthamo omkhulu wansuku zonke ungaba ngu-480 mg.
Ukuphindaphindwa kwesicelo kungokwesithathu kuya kwesine ngosuku. Thatha imithi ngesikhathi sokudla noma ngokushesha ngemva kokudla, ngaphandle kokukhohlwa ukuphuza amanzi amancane.
I-contraindicated ekusetshenzisweni kwe-Verapamil kubantu abane:
- ukuphazamiseka kwengqondo;
- i-bradycardia eyaziwa;
- i-hypotension ye-arterial;
- isifo sobuthakathaka se-sinus node;
- Ukuvinjelwa kwe-AV yesilinganiso sesi-2-3;
- ukuhluleka kwenhliziyo engapheli yesigaba sesi-2-3;
- I-Wolff-Parkinson-White syndrome;
- ukuhluleka kwenhliziyo enzima;
- i-hypersensitivity ekubunjweni komuthi.
Isidakamizwa sinemiphumela emibi esithinta ama-body main systems:
Uhlelo lwesimo senhliziyo:
- ukunciphisa okukhulu kwegazi;
- i-bradycardia;
- ukuhlukumeza nokuthuthukisa ukuhluleka kwenhliziyo;
- i-arrhythmia;
- ukuwa.
Uhlelo lwesimiso se-peripheral ne-CNS:
- ikhanda;
- isiyezi;
- ukuphelelwa amandla;
- ukukhathazeka;
- ukhathala okwandayo;
- ukucindezeleka;
- ukulala;
- ukuphuza;
- ukuthuthumela kweminwe;
- i-ataxia;
- ukuthukuthela;
- ubunzima bokugwinya.
3. Uhlelo lokugaya:
- ukuqotshwa;
- isicasuli;
- ukuphuma nokuvuvukala kwezinsini;
- ukwandisa ukudla.
4. Ukuphendula kwe-allergen:
- itching;
- ukuqhuma;
- i-erythema;
- i-hyperemia yesikhumba sobuso.
Imiphumela emibi yokuthatha lesi sidakamizwa yilezi:
- inzuzo yesisindo;
- ukulahlekelwa okwesikhashana kombono;
- i-edema yamapulmari;
- i-arthritis;
- i-edema yedolobha.
I-Verapamil ngokuqapha okukhulu kunqunywe uma isiguli sithi:
- umsebenzi wesibindi okhubazekile;
- kwakukhona i-infarction eyingozi ye-myocardial.
Kuyinto engathandeki ukuphuza imithi ngabantu abahlanganyela emisebenzini engaba yingozi, okudinga ukunakekelwa okukhudlwana nokuphendula okusheshayo, omama abakhulelwe nabanomsoco.