Ama-antibodies kuya ku-thyroglobulin - lena yiyona ipharamitha eyinhloko yokuthola izifo ze-autoimmune ze-autoimmune, isifo se-Hashimoto, isifo se-goiter esiyingozi, njll.
Iyini i-thyroglobulin?
Eqinisweni, i-thyroglobulin iyi-glycoprotein, eyingxenye ye-colloid ye-follicles ye-gland yegciwane. Yenza umsebenzi we-propeptide ekuqaliseni kwamahomoni wegciwane. Ngamazwi alula, i-thyroglobulin ingabonakala njengeprotheni elitholakala ngaphakathi kwe-follicles ye-gland yegciwane. Inqubo yokufihla ama-hormone thyroglobulin ngesilinganiso esincane siwela egazini. Ngokusho kwemithi ethile, imithi engaziwa, izizathu, ingaba i-autoantigen, lapho umzimba uqala ukukhiqiza amantombazane. Ama-antibodies, ukuxhuma ne-receptors ye-thyroglobulin, uqala ukulingisa isenzo se-hormone. Kulokhu, igciwane le-thyroid liqala ukuhlinzeka umzimba ngamahomoni ngobuningi obukhulu, liphazamise umzimba kanye nomsebenzi wenhliziyo.
Ama-antibodies ku-thyroglobulin anqunywa ngenhloso yokuxilongwa kwezifo ze-thyroid ngokushesha. Ngakho-ke, bangakuvimbela kanjani i-thyroglobulin, kuyilapho bephazamisa ama-hormone e-thyroid ejwayelekile. Lapho ama-antibodies e-thyroglobulin ekhuphuka, angabangela ukuvuvukala kwegciwane le-thyroid, hypothyroidism noma, ngokuphambene nalokho, kushukumisa ngokweqile ukugcoba futhi kubangele ukucindezeleka ( hyperthyroidism ).
Ama-antibodies kuya ku-thyroglobulin - evamile
Ama-antibodies kuya kwe-thyroglobulin yinoma yiliphi inani le-U / ml ebangeni kusukela ku-0 kuya ku-18. Ngakho-ke, kungaphetha ngokuthi ama-antibodies ku-thyroglobulin awayehliswa.
Ama-antibodies kuya kwe-thyroglobulin ngaphezu kwesimiso angatholakala kubantu abanempilo ngokuphelele. Kulesi simo, emadodeni omzimba we-thyroglobulin akhula kakhulu kunabesifazane, ikakhulukazi abesifazane asebekhulile.
Indlela yokunquma inani lama-antibodies ku-thyroglobulin?
Inani lama-antibodies ku-thyroglobulin emzimbeni lenziwa ngokuhlaziya igazi kusuka emthonjeni we-ulnar. Lokhu kuhlaziywa kunikezwe isigaba esithile sabantu, okungukuthi:
- iziguli ezine-hypothyroidism (i-subclinical noma ebonakalayo) ukukhomba imbangela yokubonakala kwayo;
- ukucacisa imbangela yokwanda ngobuningi begciwane le-thyroid;
- iziguli ezithola i-interferon nezidakamizwa ze-lithium, i-amiodarone. Iziguli ezithathelwa ama-antibodies ku-thyroglobulin zanda, ngemuva kokuthatha lezi zidakamizwa nazo zingathola isifo se-thyroid;
- i-fuddled, uma unina unezinhlamvu zokulwa ne-thyroglobulin ngaphezu kwesijwayelekile.
Ngenxa yokuhlaziywa kwama-antibodies kuya kwe-thyroglobulin kungenzeka ukuhlola imisebenzi yegciwane le-thyroid, ukusekela isimo sesifo sayo kanye nenqubo yokwelapha, ukuveza izifo ezithintekayo.
Ama-antibodies ku-thyroglobulin angaphezu kwejwayelekile
Uma ama-antibodies ku-thyroglobulin enyuka, izizathu zingaba khona kwezifo ezilandelayo:
- i-subacute noma i-chronic thyroiditis (iziguli ezingu-40-70%), i-Hashimoto's thyroiditis (iziguli ezingu-97%);
- Isifo samangcwaba (iziguli ezingama-51%);
- i-mydiema idiopathic (iziguli ezingama-95%);
- hypothyroidism (iziguli ezingu-70%);
- ihlukanisa i-goiter enobuhlungu (iziguli ezingama-40%);
- i-carcinomas ye-thymedullary (iziguli ezingu-15-30%);
- ezinye izifo zemvelo ezizimele, kufaka phakathi i-anemia eyingozi.
Ngaphezu kwalokho, uma ama-antibodies e-thyroglobulin ekhuphuka kancane, lokhu kungabonisa ukuthi kukhona okungavamile kwe-chromosomal, ikakhulukazi, i-Down syndrome noma i-Turner syndrome.
Amathuba okunciphisa izinga lama-antibodies ku-thyroglobulin emzimbeni ngokuthatha imithi iphansi kakhulu. Emithi yokwelapha yanamuhla, uma izifo ezithathelwanayo ku-thyroglobulin zanda, ukwelashwa, ukuze kutholakale izinga labo emzimbeni ngendlela evamile. Ngakho-ke, ukusetshenziswa kwe-hemosorption, i-plasmapheresis, i-corticosteroids, "ama-immunomodulator" ayinalutho futhi, ngisho, ayingozi. Ukuqokwa kwe-l-thyroxine nakho akulungile. Lesi sifo ngokwawo sitholakale ekwelapheni, eshukunyiswa ukwanda komzimba wezinga lama-antibodies ku-thyroglobulin. Ukuhlolwa kwama-antibodies ku-thyroglobulin kunqunyelwe kuphela ngenhloso yokusho noma ukuphikisa ukuxilongwa, futhi akukho ndlela yokuhlola ukuphumelela kokwelashwa. Okhulumayo uthi bafuna ukuthola imali ngesiguli, ngakho qaphela.