Ezingxenyeni eziningi, kuhlanganise nenhliziyo, kanye nemithambo yegazi, izinso, izindiza zezindiza nezinye izicubu, kunezamukelayo ze-beta-adrenergic. Bayibophezele kakhulu, futhi ngezinye izikhathi kuyingozi, ukusabela komzimba ukucindezela nokucindezeleka ("hit noma run"). Ukunciphisa umsebenzi wabo kwezokwelapha, i-beta-blockers isetshenzisiwe - uhlu lwezidakamizwa ezivela kuleli qembu lezemithi likhulu kakhulu, elivumela ukukhetha imithi efanelekayo kwesiguli ngasinye ngabanye.
I-beta-blockers engakhethi
Kunezinhlobo ezimbili ze-adrenoreceptors - i-beta-1 ne-beta-2. Uma ukuhluka okuqala kuvinjelwe, imiphumela elandelayo ye-heart iyafezwa:
- ukunciphisa kwenhliziyo nenani;
- ukuncipha kwengcindezi yegazi;
- ukucindezelwa kokuziphatha komzimba.
Uma uvimbela i-beta-2-adrenoreceptors, kunokwanda kokumelana kwamakhemikhali wegazi nezwi:
- Isibeletho (kubesifazane abakhulelwe);
- i-bronchi;
- i-arterioles.
Amalungiselelo avela kwi-subgroup ye-beta-blockers ye-nonselective ayenzi ngokukhetha, ukunciphisa umsebenzi womabili izinhlobo ze-receptors.
Imithi elandelayo ibhekisela emithini ecatshangelwe:
- Oxprenolol;
- I-Propranolol;
- Pindolol;
- Anaprilin;
- I-Sotalol;
- Penbutolol;
- I-Nadolol;
- Timolol;
- Inderal;
- Obsidan;
- Bopindolol;
- Okupres-E;
- I-Sandinorm;
- Levobunolol;
- I-Wistagen;
- I-Korgard;
- Obinol;
- I-Wistagan;
- Oxprenolol;
- I-Tracicore;
- I-Koretal;
- UVickin;
- I-Sotalol;
- Timolol;
- I-Viskaldix;
- I-Sotagexal;
- Okumol;
- Ama-Sotaleks;
- Arutimol;
- I-Xalacom;
- Okumed;
- Fotil nabanye.
I-beta-blockers ekhethiwe
Uma izidakamizwa zisebenza ngokukhetha futhi zinciphisa ukusebenza kwe-receptors kuphela ye-beta-1-adrenergic, i-agent ekhethiwe. Kufanele kuqaphele ukuthi izidakamizwa ezinjalo zithandwa kakhulu ekwelapheni kwezinkinga ze-cardiovascular, ngaphandle kwalokho, ziveza imiphumela emibi kakhulu.
Uhlu lwezidakamizwa ezivela eqenjini le-cardioselective beta-blockers yesizukulwane esisha:
- IBetacard;
- I-Atenolol;
- I-Tenolol;
- I-Prinorm;
- I-Bisoprolol;
- I-Tenoric;
- Hypoten;
- I-bisocardium;
- I-Tenoretik;
- I-Bisogamma;
- Concor;
- Lokren;
- I-Coronale;
- I-Betaxolol;
- I-Metoprolol;
- I-Betoptik;
- Corvitol;
- I-Vasocardine;
- I-Logimax;
- Egilok;
- I-metocard;
- Amzok;
- Okungeyona ithikithi;
- I-Esmolol;
- I-Breviblock;
- Nebivolol;
- I-Talinolol;
- I-Cordanum;
- Acebutolol.
Imiphumela emibi ye-beta-blockers
Izimo ezimbi zivame ukudala izidakamizwa ezingakhethi. Lezi zihlanganisa izimo ezilandelayo:
- i-bradycardia ;
- izimpawu zokuhluleka kwenhliziyo;
- i-hypotension ye-arterial;
- ubuhlungu esifubeni;
- ukuphazamiseka kokulala noma ukulala;
- isiyezi;
- ukukhubazeka kwememori kanye nekhono lokugxila;
- ukucindezeleka;
- ukubonwa okubukwayo nokuhlola;
- amandla okusebenza aphansi;
- ukunganakwa;
- ikhanda;
- isicasuli;
- umlomo owomile;
- isifo sohudo noma ukuqotshwa;
- ukuhlanza;
- ubuhlungu ku-epigastrium namathumbu;
- ukuminyanisa kwamanzi;
- i-bronchospasm;
- i-dyspnea;
- ubunzima bokuphefumula;
- i-aplastic insemia;
- purpura ye-thrombocytopenic;
- i-thromboses;
- i-hypothyroidism;
- kunciphise i-libido ne-potency;
- i-gynecomastia;
- imisipha ye-muscle;
- i-arthralgia ;
- ukuthuthumela;
- i-myasthenia gravis;
- ukoma kwe-mucosa iso;
- ukukhubazeka okubukwayo;
- ukunciphisa inani lemfucuza yezinyembezi ezikhishwe;
- i-conjunctivitis;
- ukushaya isikhumba;
- i-urticaria;
- ukujuluka okukhulu;
- ukuzwela kwesikhumba ku-ultraviolet;
- i-hyperemia ye-epidermis;
- ukuphindaphinda kwe-psoriasis;
- i-alopecia (eguquguqukayo);
- ubuhlungu ngemuva.
Ngokuvamile, ngemva kokuyeka i-adrenoblocker, kune-"withdrawal syndrome" ngendlela yokwanda okuthe xaxa nokuqhubekayo kwegazi, iziqephu eziningi ze-angina pectoris.