Ukulungiswa okuhloswe ukukhishwa kokuzivikela komuntu kuthiwa yi-immunosuppressors, elinye igama lingama-immunosuppressants. Leli qembu lezidakamizwa, njengombuso, lisetshenziselwa ukuhlinzekwa kokuhlinzwa ekufakweni komzimba.
Imithi ye-immunosuppressive - ngezigaba
Imithi ecatshangelwayo ihlukaniswe yaba ngamaqembu ahluke ngokusho komthelela wabo wokuzivikela:
- ukuvimbela ngokuphelele izidakamizwa zokuzivikela. Ama agent anjalo athinta wonke ama-subspecies amangqamuzana omzimba, ukuvimbela umsebenzi wabo;
- izifo zokuzivikela ezikhethiwe ngezinjongo ezithile zezinhlobo ezithile zamangqamuzana omzimba omzimba. Benza ngokukhetha ngokumelene, isibonelo, izindlela zokuzivikela zomzimba noma ukuguqula umzimba;
- imithi ene-anti-inflammatory effect, esetshenziswa ezimweni zokuphazamiseka kwengqondo;
- imithi ephawulekayo. Le subtype ihloselwe kuphela ukunciphisa izimpawu zezifo ezizimele.
Ama-immunosuppressants yemvelo
Ama-immunosuppressors ezemvelo angcono kakhulu ekwelapheni izifo ezizimele kanye nezicubu zomdlavuza, ngoba zinomthelela omkhulu emzimbeni. Ngaphezu kwalokho, izidakamizwa zemvelo azikho imiphumela emibi, ukwelashwa akuthinti isibindi futhi akuphazamisi ukugaya.
Enhliziyweni yama-immunosuppressants of origin origin are metabolites secondary (microbial origin), ama-microorganism, a-eukaryotes. Ngokuvamile i-Streptomyces yesisu isetshenziselwa, ngoba yibo abameleli bayo abangenayo kuphela imithi elwa namagciwane okulwa nokuvuvukala, kodwa futhi nemiphumela ye-antifuginal.
Izidakamizwa ezingenayo imithi
Phakathi kwama-immunosuppressors anqanda noma yikuphi amangqamuzana omzimba futhi avimbele ukwakhiwa kwe-lymphocytes egazini, okusetshenziselwa kakhulu ukuthi:
- I-Vero-Cyclosporin;
- I-Cycloral;
- Imuran;
- Azathioprin.
Ngokujwayelekile, izivikeli ezifakwe ohlwini ezisetshenzisiwe zisetshenziselwa ukwelashwa kwezicubu zesifo somdlavuza ekupheleni kwezinyathelo nangemva kokuhlinzwa komzimba, ikakhulukazi uma ukulahlwa kwezicubu ezinzima sekuqalile.
Ukulungiswa okukhethiwe (okukhethiwe):
- Timodepressin;
- I-Tacrolimus;
- I-Cyclosporin A.
Lawa ma-immunosuppressors ayedluli ukuvimbela isifo sokuzivikela, ungaphazamisi ukwakhiwa kwamaseli okuzivikela ezifweni ezibangelwa amagciwane noma ezithathelwanayo.
Umphumela wokulwa nokuvuvukala nokuqeda izimpawu zokugula , izibonakaliso zezifo ezizimele zihlinzekwa yimithi:
- I-Methylprednisolone;
- Fluuocinonide;
- I-Clobetasol;
- I-Prednisolone;
- I-Hydrocortisone.
Kumele kuqaphele ukuthi amalungiselelo e-glucocorticosteroid ama-immunosuppressants anemiphumela emibi kakhulu, ngokuvamile evame ukwandisa isimo sesiguli. Lokhu kungenxa yemvelaphi yabo ye-steroid: le mithi iphazamisa ukwakheka kwamahomoni adingekayo kwesibindi nezinso.