Emanzini aphezulu, i-papaverine inciphisa i-excitability yesisindo senhliziyo, iphuza ukuqhutshwa komzimba, futhi inomphumela omuhle wokudambisa. I-Papaverine hydrochloride itholakala ngendlela yamathebulethi, izixazululo zokujola kanye nezidakamizwa.
Izinkomba zokusetshenziswa kwe-suppository ne-papaverine
I-Papaverine isetshenziselwa ukunciphisa izinsalela zemisipha ebushelelezi futhi njengesifo sokubulala umzimba uma kwenzeka ubuhlungu bubangelwa ukuphahlazeka. Uma usebenzisa ama-rectal suppositories ne-papaverine, ngenxa yokwanda kwamazinga omzimba nokunikezwa kwegazi okuhle kule ndawo, amakhandlela aphela ngokushesha, futhi umuthi uyangena futhi ungene egazini. Umphumela wemiphumela yamakhandlela uvame ukufika ngokushesha kunokuba nokuphathwa ngomlomo kwesidakamizwa, ngendlela yamathebulethi. Futhi, ngalesi singeniso, lesi sidakamizwa sinomthelela omkhulu wendawo. Ngakho-ke, nge-spasms ye-muscle ebushelelezi yesigxobo esiswini (isisindo se-urinary, i-spastic colitis, i-cholecystitis), i-tract emathunjini, izitho zangasese, ama-hemorrhoids, ngokuvamile i-papaverine isetshenziselwa amakhandlela. Ngaphezu kwalokho, ukusetshenziswa kwamakhandlela nge-papaverine cishe kungenzeki imiphumela emibi nokudlula ngokweqile.
Ukungahambisani nemiphumela emibi ye-suppository ne-papaverine
Uma uthatha i-papaverine, ikakhulukazi ngesilinganiso esiphezulu, ukungaboni ngaso sonke isikhathi isidakamizwa, ubomvu nokukhwabanisa kwesikhumba ngenxa ye-vasodilation, isizungu nokulala ngenxa yokunciphisa okukhulu kwegazi, ukunciphisa isigqi senhliziyo kungabonwa.
Isidakamizwa asisetshenziselwa ukwephulwa komzimba womzimba (ukuvinjelwa), ukunyuka kwengcindezi ye-intraocular (glaucoma), okwenziwe umonakalo noma ukungenwa kahle kwe-hepatic.
Uma usebenzisa i-papaverine, akufanele ubheme uphuze utshwala. I-Nikotini inciphisa ukusebenza komuthi, futhi ngokuphawulekayo. Ukuhlanganiswa kwe-papaverine nodakwa kungabangela ukwehla okukhulu ekucindezelekeni, ukuphelelwa amandla .
Amakhandlela ane-papaverine ema-hemorrhoids
Nge-hemorrhoids papaverine isetshenziselwa kuphela uhlobo lwe-suppositories yama-rectal. Njengoba kuboniswe ngenhla, ikhandlela elifakwe ngaphakathi kwe-rectum liqala ukwenza ngokushesha, lisuse isiphithiphithi futhi likhiqize umphumela wokuzibulala. Futhi, amakhandlela ane-papaverine anomthelela omuhle we-laxative, lapho ama-hemorrhoids ehambisana nokuqothulwa kwe-spastic. Uma isiguli sinokuqothulwa kwe-atonic, ukusetshenziswa kwamakhandlela anjalo akunconywa, ngoba bangakwazi ukuqinisa ukuqothulwa futhi kubangele ukuwohloka kwesimo esijwayelekile.
Amakhandlela ane-papaverine ekukhulelwe
Nakuba iziqondiso kumuthi futhi zibonise ukuthi ukusetshenziswa kwazo ngesikhathi sokukhulelwa kanye ne-lactation akukhuthazwa, i-papaverine emakhandlela ivame ukubekwa kwabesifazane abakhulelwe ngezwi elikhulayo lesisu. Ukuqhathaniswa kwezinto kuhlotshaniswa nethonya lemiphumela ye-cardiotoxic emntwaneni, kodwa uma umuthi usetshenziselwa ukwelashwa kwemithi yokwelapha, lokhu kungenzeka kuncane kakhulu. Ngakolunye uhlangothi, amakhandlela ne-papaverine anomphumela omuhle kunawo wonke kanye nemiphumela emincane yemiphumela uma kuqhathaniswa nezinye izilinganiso zalesi sidakamizwa.
Ungabeka kanjani amakhandlela nge-papaverine?
Ama-suppository ane-papaverine akhiqizwa esilinganisweni sama-20 no-40 μg emuthi ekhandleni elilodwa. Kuhlale kululeka ukuqala ukwelashwa ngesilinganiso esincane, futhi ukwandise kuphela uma ukwelashwa kungasebenzi. Amakhandlela ajojelwa ku-anus kusukela ku-1 kuya kwezingu-3 ngosuku, ngokuhlelekile emva kokuhlanza i-rectum, njengalokhu kusetshenziswa, ukusetshenziswa kwezidakamizwa kuzosebenza kangcono. Amakhandlela ane-papaverine angasetshenziswa nsuku zonke, afunde kuze kube yizinsuku ezingu-10, noma ngokuphawulekayo, uma izikhalazo zenzeka. Isikhathi eside (izinsuku ezingaphezu kwezingu-10) ukusetshenziswa kwansuku zonke kwe-papaverine akunconywa, ngoba kungabangela ukugula, ukuxoshwa, isisindo, isizungu, ukujuluka ngokweqile, ukuphazamiseka kwamathumbu.