I-Gilbert's syndrome - izimpawu

I-Gilbert's syndrome (isifo sikaGilbert, i-jaundice yomndeni ongewona i-hemolytic, i-cholemia elula yomndeni, i-hyperbilirubinemia yomthethosisekelo) yisifo esiyinzalo enesifo esibucayi, esibangelwa ukuguqulwa kwesakhi sofuzo okuphethwe yi-bilirubin esibindi. Lesi sifo sabizwa nge-gastroenterologist yesiFulentshi u-Augustine Nicolas Gilbert, owaqala ukuyichaza ngo-1901. I-Gilbert's syndrome ngokuvamile ibonakala njengezinga eliphezulu le-bilirubin egazini, i-jaundice nezinye izibonakaliso ezithile ezingekho eziyingozi futhi azidingi ukwelashwa okuphuthumayo.

Izimpawu zikaGilbert's Syndrome

Izimpawu eziyinhloko zalesi sifo zihlanganisa okulandelayo:

1. I-Jaundice, lapho kuqala ibona i-icteric staining ye-sclera yeso (kusuka cishe engaphendulwanga ukubizwa). Ezimweni ezingavamile, kungase kube khona ukukhishwa kwesikhumba esikhwameni se-nasolabial, izintende zezandla, izintambo.
2. Ukunganaki ku-hypochondrium elungile, kwezinye izimo, kungase kube nokwanda kancane kwesayizi sebindi.
3. Ukubuthakathaka jikelele nokukhathala.
4. Kwezinye izimo, ukuhlukumeza, ukuguqulwa, ukuphazamiseka kwesitokisi, ukungahambisani nokudla okuthile kungenzeka.

Isizathu se-Gilbert's syndrome ukungenwa kwesibindi se-enzyme ekhethekile (glucuronyltransferase), okubangela ukushintshaniswa kwe-bilirubin. Ngenxa yalokho, kufike ku-30% kuphela inani elijwayelekile le-pigment ye-bile enqanyuliwe emzimbeni, futhi okweqile kudonsa egazini, okubangela uphawu oluvame ukwanda kwalesi sifo - i-jaundice.

Ukuxilongwa kweGilbert's Syndrome

Ukuxilongwa kwe-Gilbert's syndrome ngokuvamile kuxhomeke ekuhlolweni kwegazi:

1. Isilinganiso se-bilirubin esiGilbert's syndrome sisukela ku-21 kuya ku-51 μmol / l, kepha singakhuphuka sibe ngu-85-140 μmol / l ngaphansi kwethonya lokuzikhandla ngokomzimba noma nezinye izifo.
2. Isibonelo ngendlala. Ibhekisela ekuhloleni (okungavamile kakhulu) ukuhlolwa kwe-Gilbert's syndrome. Ngokweqile kokuzila noma ukuhambisana phakathi kokudla okuphansi kwezinsuku ezimbili , i- bilirubin ekukhuleni kwegazi ngo-50-100%. Izindlela ze-bilirubin zenziwa ngesisu esingenalutho ngaphambi kokuhlolwa, bese emva kwezinsuku ezimbili.
3. Isampula nge phenobarbital. Uma uthatha i-phenobarbital, izinga le-bilirubin egazini lehla kakhulu.

Ungaphila ne-Gilbert's syndrome?

Lesi sifo ngokwawo asibhekwa njengengozi futhi ngokuvamile asidingi ukwelashwa okuqondile. Nakuba izinga eliphakeme le-bilirubin egazini liphikelela kulo lonke ukuphila, kodwa izinga layo eliyingozi alifinyeleli ezingeni eliyingozi. Umphumela wezibonakaliso zikaGilbert ngokuvamile ukhawulelwe ukubonakaliswa kwangaphandle nokungahambi kahle, ngakho-ke, ngaphezu kokudliwa, ukwelashwa kusebenzisa kuphela ukusetshenziswa kwe-hepatoprotectors ukuthuthukisa ukusebenza kwesibindi. Kanti futhi (ezimweni ezingavamile, i-jaundice enzima) ukuthatha izidakamizwa ezisiza ukukhipha ukugqothula okugqamile emzimbeni.

Ngaphezu kwalokho, izimpawu zalesi sifo azihlali unomphela futhi isikhathi esiningi singakwazi ukungaqondakali, sikhule ngokuzikhandla ngokweqile, ukuphuza utshwala, indlala, amakhaza.

Into kuphela engaba yingozi yi-Gilbert's syndrome - ezimweni ezingavamile, uma umbuso ungahlonishwa futhi udla ukuphazamiseka, kubangele ekuthuthukiseni ukuvuvukala kwe-biliary tract kanye ne- cholelithiasis .

Futhi kufanele kukhunjulwe ukuthi lesi sifo sinesizungu, ngakho-ke uma kukhona umlando womunye wabazali, kunconywa ukuba uthintane ne-geneticist ngaphambi kokuhlela ukukhulelwa.