Esinye sezidakamizwa ezithandwa kakhulu yi-antiviral kanye ne-immunomodulating, i-Interferon Alpha, umkhiqizo wobunjiniyela bezakhi zofuzo. Isekelwe kumaprotheni ahlanzekile, okuyi-analog yeprotheyini yegazi lomuntu futhi ubizwa ngokuthi i-interferon. Kungaba ngezinhlobo ezimbalwa, kodwa amalungiselelo asekelwe amaprotheni e-interferon alfa ahlukaniswa yi-bioavailability ephakeme kakhulu.
Ifomu lokukhululwa i-Interferon Alpha
Kunezindlela eziningi kakhulu zokusebenzisa lesi sidakamizwa, ngakho ukukhululwa kwezinhlobo ezahlukene zezidakamizwa kulungiswa ngokwemithi:
- I-powder eyomile esetshenziselwa umjovo ngokuhlanganiswa namanzi ase-distilled;
- isisombululo esilungele umjovo;
- ama-suppository angama-rectal;
- i-ointment;
- amaconsi emisipha;
- i- spray ;
- amaconsi eso;
- i-powder eyomile yokulungiselela amaconsi ensipho neso.
Ukusetshenziswa kwe-Interferon Alpha
Ukwelapha nge-Interferon Alpha kusekelwe emthonjeni omkhulu we-antiviral. Kuye kwaphawula isikhathi eside ukuthi umuntu othuthukisa igciwane elilodwa emzimbeni angeke athole igciwane lesinye uhlobo lwegciwane. Ngokusungulwa kwe-interferon, amangqamuzana lapho igciwane lingakafiki khona, liba ngumelana nalo futhi ekugcineni lesi sifo siphelile. Njengoba lolu hlelo lufanelekile ngamagciwane kwanoma yiluphi uhlobo, ububanzi be-Interferon Alpha bubanzi kakhulu:
- i-hepatitis ye-viral yimuphi uhlobo;
- i-conjunctivitis;
- ukutheleleka kwesisu nesifo sofuba;
- I-SARS , umkhuhlane;
- i-laryngeal papillomatosis;
- i-myeloma eminingi;
- i-leukemia;
- Sarcoma Kaposi;
- i-lymphoma;
- i-carcinoma;
- ukutheleleka kwegciwane lesandulela ngculazi ne-bactericidal kwanoma yiluphi uhlobo ezinganeni.
Ngokungafani nezinye izidakamizwa ze-antiviral ezivela emthonjeni, i-interferon inezinkomba ezimbalwa. Isetshenziswa ngokucophelela uma kwenzeka izinkinga ngezigameko zokweqa kanye nezinye izifo zesibindi. Ngesikhathi sokukhulelwa kanye ne-lactation lesi sidakamizwa sithathwa ngokuqinile ngokwemithi kadokotela. Imiphumela emibi ye-Interferon Alpha ayikwazi ukubizwa ngokuthi iyamnandi, kodwa ayivamile. Lezi yizi:
- izikhukhula;
- umkhuhlane;
- isicasuli;
- ukulala.
Kubalulekile ukwazi ukuthi le mithi ayihlanganisi kahle kakhulu nezinye izidakamizwa nemithi, ngakho kufanele uthintane nodokotela mayelana nokusebenzisa ngamunye wabo. Lokhu kuzosiza ukugwema izinkinga ezinkulu. Kuyinto engathandeki kakhulu ukuthatha i-interferon kanye nezidakamizwa nemithi yezidakamizwa.
Indlela yokufaka i-Interferon Alpha nge-powder, incike emigomweni. Isilinganiso esidingekayo salesi sidakamizwa kumele sihlanjululwe ngaphambili ngamanzi a-distilled yomjovo ngesamba sama-50 ml. Uma kwenzeka udinga amaconsi ekhaleni lakho, noma amehlo, ungasebenzisa futhi u-saline (i-chloride ye-sodium) ngale njongo.
Amaconsi ama-Eye i-Interferon Alpha nezinye izinhlobo zemithi alungele ukusetshenziswa futhi ayidingi ukungezwa kwezingxenye ezengeziwe.
Ama-Analogues we-Interferon Alpha
Kuze kube manje, kunezidakamizwa eziningi ezisekelwe kuma-interferon ahlukahlukene. Ezinye zazo zivela empumalanga, ezinye zivela emakhaya, kodwa izinga lokusebenza kwalo lonke le mithi cishe lifanayo. Umehluko okuwukuphela kwekhwalithi yamaprotheni ukuhlanzwa futhi, ngakho-ke, intengo. Nasi uhlu lwemithi engathatha indawo ye-Interferon Alpha:
- Alfarekin;
- I-Intron A;
- I-Roferon;
- I-Nasoferon;
- I-Vellveron;
- i-interferon leukocyte yabantu nabanye.
Zonke lezi zidakamizwa zenzelwe ukuphatha ukubonakaliswa kwamagciwane ahlukahlukene, ukuvimbela ukusabalalisa komzimba, ukuvimbela ukutheleleka kwamaseli amasha, ukuqinisa i-membrane yeseli. Ngenxa yokuhlanganiswa kwama-enzyme ohlobo oluthile, umzimba uqinisa isimiso somzimba sokuzivikela futhi uqala ukulwa okuzimele nokulwa nesifo. Futhi ama-interferons azo zonke izinhlobo anomphumela wokuphikisa, izimbangela zazo ezingazange zenziwe ngokunembile ukuba zidlule, noma kunjalo, ukusetshenziswa kwezidakamizwa zokwelashwa nokuvinjelwa komdlavuza akuvunyelwe.