I-Nimesil no-alcohol

Izidakamizwa ezenza izidakamizwa ezinamandla ngezikhathi ezithile ziqukethe ama-antibiotics ekubunjweni. I-agent engaphansi kokucubungula ayisebenzi kubo, nakuba kuyi-analgesic esebenzayo kakhulu. Noma kunjalo, uNimesil no-alcohol ngokuvamile abanakudliwa ngosuku olulodwa, ngoba lokhu kungaholela emiphumeleni engavumeleki emzimbeni.

Ukuhambisana kwe-Nimesil nokuphuza utshwala

Ukuhlanza u-ethyl utshwala kwenzeka esibindi, kuyilapho kukhiqiza isishukela esibizwa ngokuthi i-acetaldehyde. Izingxenye zokuphuza utshwala azitholakali ekufeni, kanti ukuhlukumeza utshwala kuholela ekuthathweni kwezicubu ze-hepatic yizicubu ezixhunyiwe. Ngakho-ke, iziphuzo ezinamandla zinomthelela onobuthi emzimbeni, zibhubhisa amaseli wesibindi. Isakhi esisebenzayo seNimesil yi-nimesulide, into engeyona i-steroidal elwa nokuvuvukala, okungezelela ukuthi i-anesthetizing, iveza umphumela we-antipyretic. I-toxin ebuthakathaka, efana ne-acetaldehyde, ekwazi ukubhubhisa amaseli wesibindi kumanani angaphezu kwalawo anconyiwe emiyalweni. Emiphumeleni emibi eya kumuthi obuzwayo, kuboniswa ukuthi enye yemiphumela emibi yokwelashwa kwemithi ingase ibe ukwephula ukusebenza kwesibindi, kanye nesifo sofuba . Ngakho-ke, i-Nimesil no-alcohol bayathandeki ukuhlanganisa, ngoba ukusebenzisa ngesikhathi esisodwa izinto ezinobungozi ku-organ-forming cross-kuqinisa isenzo sabo.

Kungenzeka yini ukuthatha uNimesil ngotshwala, futhi ukuxhumana kwabo kuyini?

Emfundisweni eya kumuthi ochazwe, ayikho inkomba yokuthi uNimesil no-alcohol abahambisani, futhi akukho ncazelo yezinqubo zokuxhumana. Kodwa kufanele kuqashelwe ukuthi i-metabolism (cleavage) ye-nimesulide ikhona ngokuhlanganyela kwe-enzyme ekhethekile-isoenzyme cytochrome. Njengoba kunjalo, liphinde likhuthaze ukuwohloka kwe-ethanol compounds esibindi. Ngakho-ke, ukusetshenziselwa kwesidakamizwa utshwala ngesikhathi esifanayo kwenza kube khona ukukhiqizwa kwalesi enzyme futhi, ngenxa yalokho, ukwanda komthwalo onobuthi esibindi.

Ngaphezu kwalokho, ngenxa yokuntuleka kocwaningo mayelana nokuxhumana kukaNimesil neziphuzo ezinamandla, abukho ubufakazi bokuthi leli thuluzi lizophumelela kanjani. Phakathi kochwepheshe, kukholelwa ukuthi utshwala luvimbela umsebenzi womuthi, futhi isenzo esanele se-analgesic asitholakali.

Enye yemiphumela eyingozi kakhulu yokuthatha i-Nimesil ngotshwala yithuba lokungaboni ukuthi imiphumela emibi yokwelashwa njengokwelapha kwangaphakathi emgodleni wesisu ngenxa yokudakwa. Esimeni esingenalwazi, ukungazinaki uphawu olunjalo kungaholela ekufeni.

I-Nimesil ngemuva kokuphuza utshwala - ukulimala

Kukhona amacala lapho emva komkhosi kunenhloko ekhanda noma izifo ezingapheliyo eziqhubekayo, zihambisana nezinzwa ezingathandeki kakhulu. Ngokuvamile, udinga ngokushesha ukuqeda ukungahambi kahle futhi ngokuvamile usebenzise uNimesil ngalokhu. Kubalulekile ukukhumbula ukuthi igebe phakathi kwesigaba sokugcina sotshwala, ngisho non-eqinile, isibonelo, ubhiya, futhi ukuthatha imithi kumele kube okungenani amahora ayisithupha. Phakathi nalesi sikhathi, iningi le-ethyl utshwala lizoxilongwa esibindi futhi lisuswe kwi-bile nangasese. Nakuba umphumela onobuthi we-acetaldehyde okwakhiwe uzoqhubeka, awukwazi ukuthuthukisa kakhulu umphumela ofanayo we-nimesulide, futhi ukwelashwa kwesifo sobuhlungu kuzohlala kuphephile. Noma kunjalo, kunconywa ukuba ubeke esikhundleni somuthi osubuzwayo nge-agent engcolile (i-Aspirin, i-Ibuprom) ukuze ugweme imiphumela emibi yesibindi.