Izindlela zokwelapha uhlobo lwe-2 lwesifo sikashukela zihloswe ukukhokhela imetabolism ye-carbohydrate. Ngenxa yalokhu, kusetshenziswa izindlela ezintathu eziyinhloko: ukunamathela ekudleni okukhethekile, ukuvivinya umzimba nokusetshenziswa kwezidakamizwa ze-hypoglycemic.
Ukusetshenziswa kwemithi ye-hypoglycemic ye-type 2 yesifo sikashukela kudinga indlela enzima. Ukukhethwa kwala mithi kanye nomthamo wabo kuthathwa ngudokotela oya khona, ngenkathi egxile esimweni sesiguli, izinkomba zeshukela kanye nomchamo wamanzi, inkambo nokuqina kwesi sifo, nezinye izindlela.
Kumele kucatshangwe ukuthi isidakamizwa esifaneleka kwesiguli esisodwa singase singanikezi kahle komunye noma singaphikiswa. Ngakho-ke, lezi zidakamizwa kufanele zisetshenziswe ngokuqinile ngokwezinhloso futhi ngaphansi kokuqondiswa kochwepheshe.
Ukuhlukaniswa kwamathebhulethi okunciphisa ushukela
Imithi ye-hypoglycemic ye-oral ihlukaniswe yaba izinhlobo ezintathu eziyinhloko kuye ngokuthi ifomu lamakhemikhali kanye nendlela yokusebenza emzimbeni wesiguli.
Sulfonamides
Imithi ejwayelekile kakhulu enomthelela omkhulu, okungukuthi:
- kusebenze ukwakheka kwe-insulini;
- ukwandisa ukuzwela kwezitho kanye nezicubu ku-insulin;
- okuholela ekunyuseni kwenani lama-receulin receptors kumaseli;
- ukunciphisa ukubunjwa kwe-glucose nokwandisa ukukhanya kwayo.
Okuvame ukusetshenziswa kakhulu yisizukulwane esisha semithi ye-hypoglycemic evela kuleli qembu ngokusekelwe kulokhu okulandelayo:
- i-glibenclamide (i-Maninil);
- I-Glylazide (I-Diabeton, i-Glidiab);
- glikvidon (Gljurenorm);
- i-glimepiride (i-Amaryl, i-Glemaz).
Biguanides
Izidakamizwa, indlela yokusebenza ehambisana nokuthuthukisa ukumuncwa kwe-muscle glucose . Lezi zidakamizwa zithinta ama-receptors amangqamuzana, cindezela ukwakheka kwe-glucose nokumathwa kwayo emathunjini. Kodwa-ke, zifaka isandla ekuveleni kwe-hypoxia yezicubu. Uhlu lwemithi enjalo lufaka amaphilisi asekelwe ku-metformin:
- I-glucophage;
- Siofor;
- I-Metogamma.
Ama-inhibitors we-alpha-glucosidase
Kusho ukuthi isenzo esisekelwe ekunciphiseni ukunyuka kwe-glucose emathunjini nokungena kwayo egazini. Zisebenza kahle kakhulu ezingeni eliphakeme le-glycemia emva kokudla nokuzila okuvamile. Nokho, ngokuvamile lezi zidakamizwa zihlangene namanye amaphilisi okunciphisa ushukela. Lokhu kufaka amaphilisi:
- ngesisekelo se-acarbose (Glukobay);
- esekelwe miglitol (Diastabol).