I-De-Nol iyilungiselelo eliphumelelayo lezokwelapha elisetshenziselwa ukwelapha izifo zesigcawu somathumbu. Imithi isiza ukuqinisa ukuvikelwa kwe-epithelium ye-mucosa yesisu kanye nokuvuselelwa kwayo ngemuva kokulimala yi-hydrochloric acid eyenziwa ngumzimba. Ukuziqhenya kwesidakamizwa De-Nol yisenzo sayo sokulwa namagciwane ngokumelene ne- chylobacter pylori - ibhethri ebangela izidumbu zesisu, isisu kanye ne-duodenum.
Ama-analogs kanye nama-Substitutes we-De-Nol
Ama-Analogues we-De-Nol amaphilisi ngokusho isithako esebenzayo yilezi:
- Novobispol;
- I-biskol;
- I-Biscol-Citrate;
- I-ventrisol;
- I-Vis-Nol;
- I-Duosol;
- I-Tribimol;
- Ulceron.
Ukwakhiwa kwamalungiselelo kubandakanya i-bismuth tricalium dicitrate. Kanye no-De-Nol, ama-analogs alo anemiphumela emibi kakhulu, ephikisana nokuvuvukala kanye ne-antimicrobial. Emvelweni we-acidic yesisu, into esebenzayo, uma ihlangene ne-substrate yamaphrotheni, idala ifilimu evikelayo phezu kwezinguquko kanye nokubunjwa kwesilonda.
Umphumela ofanayo wezokwelapha unomqondo ongafanelwe we-drug-de-Nol, ongowenhlangano efanayo yezokwelapha ze-gastroprotectors. Okuthandwa kakhulu phakathi kwabo yi:
- Sucralfate;
- I-Carbenoxolone;
- Misoprostol;
- I-Alsukral;
- I-Sukrat;
- U-Ulgastan nabanye.
Ake sinikeze incazelo efanisayo yokufaniswa kwe-nonstructural ye-de-Nol imithi.
Sucralfate
I-sucralfate (noma i-Venter) iqukethe isakhi esisebenzayo - usawoti we-aluminium, ukuze umuthi ungatholi i-bile acids. Kodwa kulokhu lesi sidakamizwa asikwazi ukusebenza ekulweni ne-hylebacter pylori, asenzi isithiyo sokuzivikela epithelium ezindongeni zesisu. Ngaphezu kwalokho, i-Sucralfate inemiphumela emibi kakhulu nokuphikisana okuzoyisebenzisa. Ngakho, ngaphezu kokuvinjelwa okuvamile, amaphilisi akufanele futhi asetshenziswe ekwelapheni izingane ezingaphansi kweminyaka engama-4 ubudala, i- dysphagia noma ukuvinjelwa kwesigca esiswini, ukuphuma kwegciwane lesisu.
I-Carbenoksolon
I-Carbenoksolon (noma i-biogastron) iqukethe into esebenzayo - i-extract ezimpandeni zelayisensi. Isidakamizwa sisiza ukwandisa ukucwiliswa kwesisu esiswini semfihlo ngenkathi ukwandisa i-viscosity yayo, okuthinta kakhulu ukwakhiwa kwesithintelo sokuzivikela. Ngesikhathi esifanayo kunezimo ezimbi ezibangelwa umfutho wegazi ophakeme, ukuvuvukala kwamagatsha nokuhlanza i-potassium egazini.
Misoprostol
Isidakamizwa esiyinkimbinkimbi Misoprostol singeqembu le-prostaglandins - ama-hormone-like agents. I-Misoprostol ithuthukisa kakhulu ukugeleza kwegazi kuma-capillaries we-mucosa esiswini, kwandisa ukwakhiwa kwe-mucus, kuyilapho kunciphisa ukukhululwa kwe-pepsin. Kanye no-De-Nol, i-misoprostol isheshayo ukuvuselela izinqubo ku-gastritis nesilonda esiswini, kanye ne-duodenum. Uma uthatha lesi sidakamizwa, imiphumela emibi ingenzeka, efana naleyo eyenzeka ngohlelo lwe-De-Nol.
Izindleko eziqhathaniswa nezidakamizwa zeDe-Nol nezifanekiselo zayo
Kuyafaneleka ukugcizelela ukuthi ama-analogue amaningi kaDe-Nol ayhibhile kakhulu. Isibonelo, izindleko ze-analogue ezithandwayo zesakhiwo se-De-Nol izidakamizwa ze-Novobismol, ngokwesilinganiso, i-$ 13, kanti inani lamathebulethi De-Nol kumaketanga ekhemisi linamaphesenti angu-1.5 aphezulu - cishe amakhilomitha angu-18. Cishe kabili eshibhile esinye isifaniselo esakhiwe samaphilisi e-Vis-Nol.
Ama-analogues amaningi ka-De-Nol, ayingxenye yezinsizakalo zokudla, abiza ngisho nangaphansi. Ngakho-ke, izindleko ze-Sucralfate (Venter) cishe ziyi-4 cu. Okuhlukile yi-Misoprostol. Lona imithi ebiza kakhulu, intengo yephakheji enezibhebhe ezintathu ifinyelela ku-$ 50.