Imithi yokwelashwa i-Metformin ingokwamaqembu e-hypoglycemic. Iminyaka engaphezu kwamashumi amahlanu i-Metformin isetshenziselwe ukwelashwa, ikakhulukazi isifo sikashukela. Into esebenzayo yalesi sidakamizwa inomphumela olandelayo emzimbeni:
- kunciphisa okuqukethwe okushukela egazini ;
- kunciphisa ukudla;
- ukuqinisa i-lipolysis - ukusabela kwamafutha okushisa.
Izinkomba zokusetshenziswa kwe-Metformin
I-Metformin ibangelwa izifo ezilandelayo:
- isifo sikashukela soluhlobo lwesibili, kufaka phakathi ezimweni ezihambisana nokukhuluphala;
- Isifo sikashukela sofuzo - isifo esihambisana nesifo se-carbohydrate metabolism ngemuva kwezinguquko ze-hormone kubesifazane abakhulelwe;
- I-syndrome yama-ovaries ama-polycystic kwabesifazane abanephulwa impendulo kwi-glucose.
Futhi, i-Metformin isetshenziswe njenge-prophylactic yezimo ezisongela ukuqala kwesifo sikashukela (prediabetes). Eminyakeni yamuva, ulwazi lushicilelwe ukuthi izidakamizwa ze-hypoglycemic zinciphisa umsebenzi wezinhlanganisela ezikhuthaza ukukhula kwezicubu ezimbi emangcwabeni omzimba kanye nezicubu ezihambisana nesifo sikashukela. Lokhu kuqinisekiswa yizifundo ezenziwa ososayensi baseYunivesithi yaseMichigan (USA) naseYunivesithi yaseSouth Korea.
Ukungahambisani nokusetshenziswa kwe-Metformin
Kunezinombolo eziningi zokuphikisana nokusetshenziswa kwe-Metmorphine. Lokhu kufaka:
- umonakalo omkhulu ongakapheli ezithombeni ezihilelekile ekufakeni umzimba (isibindi, izinso namaphaphu);
- i-ketoacidosis - isifo esihlobene nokuphulwa kwe-carbon metabolism ngenxa yokukhiqizwa kwe-insulin enganele;
- i-infarction ye-myocardial;
- i-laktatsidoz - isifo, ngenxa yokuthi umzimba uqoqa inani elikhulu lactic acid;
- izimo ezihambisana nokuphelelwa amandla kwamanzi (ngenxa yezifo, ukuhlukunyezwa ngokomzimba) nokuthola ngezindlela zokudla eziphansi kwekhalori;
- i-hypersensitivity ezingxenyeni zomuthi.
Ngokunakekelwa okukhethekile uMetformin isetshenziselwa ekwelapheni abesifazane abakhulelwe nabalahlayo, kanye neziguli ezineminyaka engaphezu kwengu-60.
Imithi ye-Metformin yokwelapha isifo sikashukela
Amathebulethi ase-Metformin kufanele athathwe ngemva kokudla, umthamo wesidakamizwa uncike ekutheni i-insulin isetshenziselwa ukuphatha isiguli noma cha. Kulesi simo, kunikezwa:
- Kubantu abangathathi i-insulini, amaphilisi amabili (1 g) kabili ngosuku ezinsukwini ezintathu zokuqala, kusukela osukwini lwesine kuya ku-14-day-2 amaphilisi angu-3 ngosuku. Kusukela ngosuku lwe-15, umthamo uyancipha ngokuvumelana nezincomo zesidokotela kuye ngokuthi okuqukethwe kweglucose kumanzi egazi (umchamo negazi).
- Ngokusetshenziswa kwesisodwa ngesikhathi esisodwa nge-insulin ngemali engama-40 ngosuku, i-metformin isilinganiso esifanayo, kepha isilinganiso se-insulin sinciphisa kancane kancane amayunithi amane ngosuku.
- Ngomthamo we-insulini ezingaphezu kuka-40 amayunithi ngosuku, kuhlanganise nokwelashwa kwe-Metformin, kubalulekile ukunciphisa umthamo we-insulin kuphela uma isiguli
ngaphansi kokulawulwa kwezokwelapha njalo, isibonelo, lapho uhlala esibhedlela.
Isilinganiso se-Metformin esingeziwe singabangela i-hyperglycemia - ukwanda kwamazinga e-glucose nesimo esibi nakakhulu - ku-coma ye-hyperglycemic nemiphumela engaba yingozi. Kulokhu, kubalulekile ukuqapha njalo izinga le-glucose. Ukweqa kwezinga lakhe kuyisignali yokuthi ukuthatha isidakamizwa kufanele kuphazanyiswe izinsuku ezimbalwa bese ushintshela ku-insulin.
Ukunakwa sicela! Ukwelapha isifo sikashukela nge-metformin ngaphandle kokusetshenziswa kwesinye isikhathi semithi kungabangela ubuthakathaka nokulala . Lokhu kungenxa yokuthi into esebenzayo inciphisa okuqukethwe kwe-glycogen. Ukuqeda isimo esingathandeki kunconywa ukwenza umjovo we-insulini.