Ukuze silwe nezifo ezifakwe yizifo, izidakamizwa eziningi zikhiqizwa namuhla. Futhi ngaphambi kokuba udokotela ngamunye abe nokukhetha okunzima komuthi omuhle kunayo yonke kulokhu noma kunjalo.
Amathebulethi e-Ketoconazole noma amanye amalungiselelo asekelwe kuwo angama-antifungal actif of action eziningi. Basiza ukuphatha izifo ze-systemic, okungukuthi, izifo ezibangelwa i-fungus, kanye nezifo ezifakwe emangcwabeni - ama-mycoses, i-seborrhea.
I-Ketoconazole inomthelela omubi kwi-fungus-efana ne-fungus ye-genus Candida, i-dermatophytes, isikhunta isikhunta, izifo ezihlukahlukene ze-mycoses yesistimu ngisho ne-staphylococci ne-streptococci.
Amaphilisi aKetoconazole anqunywe nini?
Izimpawu zokusetshenziswa kwe-ketoconazole yizi:
- ukutheleleka kwe-fungal ye-tract digestive;
- ukutheleleka kwe-fungal ye-urino-izitho zangasese, kuhlanganise ne-candidiasis yama-vagin, eyaziwa kangcono ngokuthi i-thrush, kanye ne-candidiasis engavamile yesisu;
- i-mycosis yezipikili, isikhumba, izinwele, i-paronychia, i-folliculitis;
- i-seborrheic dermatitis (i-dandruff);
- septicemia fungal;
- i-mycosis iso;
- i-mycoses yesimiso - candidiasis, i-blastomycosis, i-histoplasmosis, njll;
- ukuvimbela ukutheleleka kwezifungulu kubantu abane-immunodeficiency kanye nengozi eyengeziwe yezilonda zefungal.
Uma kuthathwa ngomlomo, amalungiselelo amaphilisi nge ketoconazole ahlinzeka ngempumelelo yokwelashwa kwama-surface and systemic mycoses. Isenzo salokhu kuhlobene nokubhujiswa kwenqubo ye-biosynthesis ye-ergosterol phospholipids kanye ne-triglycerides, okubandakanyeka ekwakhiweni kwesikhumba sefungal cell. Ekugcineni, ukukhula nokuphindaphinda kwalezi amangqamuzana eziyingozi kuyaphela futhi lesi sifo siphenduka.
Uma kuthathwa ngomlomo, ukulungiswa kuhlanganiswa ngokuphelele, okungukuthi, ukungena egazini, kusakazwe kabanzi kulawo makhuzu, ingxenye encane ingena emzimbeni owu-cerebrospinal. Ngemuva kokumunca emgqabeni wokugaya, isisetshenziswa esisebenzayo sihlanganiswe esibindi, sakha inombolo enkulu yametabolite engasebenzi. Lesi sidakamizwa sidonswa emcimbini (13%), sidonswe nge-bile futhi sidonswe ngamanzi (57%).
Amaphilisi ajwayelekile 1-2 athathwa ngosuku ngokudla amaviki angu-2-8, kuye ngesifo nesisindo somzimba. Isidakamizwa singasetshenziswa izingane ezingaphezu kweminyaka engu-12 ubudala.
Ukungahambisani nemiphumela emibi ngokuthatha i-Ketoconazole
Amaphilisi e-Ketoconazole avela ku-seborrheic dermatitis nezinye izifo ze-etymology ye-fungal ziphikisana ngokukhulelwa, ukwelashwa, izingane ezingaphansi kweminyaka engu-12 ubudala, abantu abane-hypersensitivity ketoconazole kanye nokukhubazeka okukhulu kwezinso zezinso nesibindi.
Imiphumela emibi yokuthatha amaphilisi kanje:
- ukuhlanzeka nokuhlanza;
- isifo sohudo;
- ukulala kwesifo;
- ukuzondwa, ikhanda;
- ukulahlekelwa kwezinwele;
- i-paresthesia;
- i-exanthema;
- isinciphiso sesifiso socansi;
- i-gynecomastia;
- i-urticaria, ukuqhuma isikhumba;
- i-photophobia;
- umkhuhlane.
Ukuphathwa komlomo ngamalungiselelo asekelwe ketoconazole kumele kuhambisane nokuphathwa kwezempilo njalo: ukuhlolwa kwegazi, hlola isibindi kanye nezinso zokusebenza. Konke okungahambisani nalokhu ekuzihloleni kanye nokwelapha ngalezi zidakamizwa. Ukwelashwa kungenziwa kuphela udokotela.
Endabeni ye-fungal meningitis, ukusetshenziswa kwe-ketoconazole akukwaziswa, ngoba leyo nto ayifinyelele kahle nge-BBB (isivinini se-hemato-encephalic).
Amalungiselelo asekelwe kulo mzimba yi-hepatotoxic, ngakho-ke indlela kufanele isetshenziswe kuphela uma inzuzo engaba khona ihlanganisa ingozi. Ikakhulukazi kulabo abagulayo ababhekene nemisebenzi ephakeme kakhulu ye-enzymes enobungozi noma abhekene nokulimala kwesibindi esibindi ngenxa yokuthatha ezinye izidakamizwa.
Amalungiselelo nge ketoconazole ezibhebheni
Nazi amagama ezithombeni zesakhiwo se-ketoconazole kumaphilisi (ngokusho kwesithako esisebenzayo):
- I-Mycosorrhal;
- I-Fungistab;
- Dermazol;
- I-Oronazole;
- I-Nizoral ;
- I-KetoconazoleAltapharm;
- I-Ketoconazole DS;
- Mikanisal;
- Livarol;
- Mikoket;
- Fungin.