Ukwephulwa kwezinqubo zokwakheka kwe-bile nokukhiqizwa kwayo kuholela ekutheni ukungeneli okwanele kwemithwalo yezinto eziphilayo ku-bile ducts. Lesi simo, i-cholestasis ye-intrahepatic, enezokwelapha ngesikhathi esifanele ayibangeli imiphumela engaphenduki. Kodwa-ke, inkinga engapheli yokugula ingadala ezinye izifo ezimbi.
Izimbangela ze-intrahepatic cholestasis syndrome
Izinto ezibangela ukuwohloka kwe-bile synthesis:
- i-hypothyroidism ;
- i-sepsis;
- ukuthatha imithi ethile;
- Isifo sika-Alagill sika;
- i-hepatitis;
- izifo ze-chromosomal;
- i-pathologies yesifo sofuba sokugaya umzimba;
- izifo ze-endocrine;
- ukungalingani kwe-hormonal ekukhutheni;
- ukuphuza utshwala;
- i-cirrhosis yesibindi;
- ukudakwa;
- ukutheleleka kwebhaktheriya;
- i-dysbiosis yamathumbu;
- i-endotoxemia.
Izimpawu nezimpawu ze-cholestasis ye-intrahepatic
Ukubonakaliswa kokuqala kwemitholampilo ye-cholestatic syndrome kubandakanya i-pruritus ne-jaundice.
I-symptomatology eyinhloko:
- ukuguqulwa kwamafutha;
- ukumnyama komchamo;
- Ukwandiswa kwesibindi ngesayizi;
- Izinhlanzi ezinamafutha;
- ukuphazamiseka kwesifo;
- umuzwa wokufutheka ngolimi;
- ngezinye izikhathi - ubuhlungu noma ubunzima ngaphansi kombambo ophansi.
Ukwelashwa kwe-cholestasis ye-intrahepatic
Ukwelashwa kwe-syndrome echazwe kuhloswe ekuqedeni imbangela eyinhloko ye-cholestasis.
Ngesikhathi esifanayo, kunikezwa ukwelashwa okusiza ekunciphiseni izimpawu kwimeko ngayinye ethize. Ukuqokwa kwenziwa kuphela nguchwepheshe ngokuhambisana nokuxilongwa, imiphumela yokuhlaziywa, izifundo zezinsimbi.
Ukuze kulungiswe imithi yokwelashwa, lezi zidakamizwa ezilandelayo zisetshenziswa:
- I-Heptral ;
- I-Ursosan;
- Rifaren;
- I-Ursofalk;
- I-Naloxone;
- Rifampicin;
- i-ursodeoxycholic acid;
- I-Metronidazole;
- I-Rifadine;
- Nalmefer;
- I-Flumecinol;
- Cholestyramine;
- Bilignin;
- Zixorin;
- I-Ondansetron.
Kubalulekile ukugcina ukudla nokuvinjelwa kwamafutha wezilwane, ukudla amavithamini.