Inqubo ngayinye yokusebenza komzimba womuntu inikezwa ama-hormone ahlukahlukene, akhiqizwa yizigulane zangaphandle.
Iyini i-ACTH?
I-hormone ye-Adrenocorticotropic iyi-hormone ye-peptide, eyenziwa yi-pituitary gland futhi ilawula umsebenzi we-correx e-adrenal. Kanti, izigulane ezinama-adrenal zikhiqiza ama-hormone e-glucocorticoid futhi ziwafaka ohlelweni lokujikeleza. Uma i-hormone ye-adrenocorticotropic ikhiqizwa ngobuningi obukhulu, ukugeleza kwegazi kuyanda emgodini we-adrenal, futhi isikhumba sikhula. Ngakolunye uhlangothi, uma i-ACTH ingakhishwa ngokwanele, ingaba ne-atrophy. I-horticone ye-corticotropic nayo yaziwa nangokuthi i-corticotropin, futhi ekusebenzeni kwezokwelapha zisebenzisa igama elifingqiwe - ACTH.
Imisebenzi ye-hormone ye-adrenocorticotropic (ACTH)
Inani lamahomoni elifihliwe yi-adrenal cortex corticotropin lilawula isimiso sempendulo: inani le-corticotropin elikhiqizwa yi-pituitary gland landa noma linciphisa njengoba kudingeka.
I-hormone ye-adrenocorticotropic ithinta ukukhiqizwa kwamahomoni alandelayo:
- i-glucocorticoids, i-cortisol ngokuyinhloko ne-cortisone, ebizwa ngokuthi ama-hormone aphikisayo nokulwa nokucindezeleka;
- ama-hormone ezocansi, okubangela ukukhulelwa nokusebenza kokuzala;
- ingxenye yokukhiqizwa kwe-adrenaline.
Ngokusekelwe kulokhu okungenhla, singaphetha ngokuthi i-horrenone ye-adrenocorticotropic iqondiswe ngqo:
- ukumelana komzimba ezifweni;
- ukuvumelanisa nezimo ezintsha;
- ukusinda ezimweni ezicindezelayo;
- ikhono lokukhiqiza inzalo.
Izinga le-ACTH egazini liyashintsha usuku lonke. Inani eliphakeme le-corticotropin liyabonwa ngehora lesi-7 kuya ku-8 ekuseni, futhi kusihlwa ukukhiqizwa kwalo kunciphisa, kwehla ekunciphiseni nsuku zonke. Ukuzivocavoca ngokweqile ngokomzimba, ukucindezeleka kanye nokuphazamiseka kwe-hormone kubesifazane kungathinta futhi inani le-horrenone ye-adrenocorticotropic egazini. Amazinga akhula noma anciphise ama-ACTH anomthelela omubi ekusebenzeni komzimba futhi angase abe uphawu lwezifo ezibucayi.
Uma i-ACTH iphakanyisiwe
I-hormone ye-Adrenocorticotropic iphakanyisiwe ezifweni ezinjalo:
- i-syndrome yokukhiqizwa kwe-ectopic ye-ACTH uma le hormone iqala ukukhiqiza isisu esiye savela kwesinye isitho;
- Isifo sika-Addison noma ukubeletha okubeletha komgogodla we-adrenal;
- Isifo se-Itzenko-Cushing, esenzeka ngenxa ye-pituitary adenoma;
- emva kokungenelela kokuhlinzekwa kokususwa kwezingqungquthela ze-adrenal;
- i-paraneoplastic syndrome, lapho kukhona ukusabela okungajwayelekile komgogodla we-pituitary kuya kwesisu esibi kakhulu, ngokuvamile emanzini.
Futhi, izinga le-ACTH landa ngokusetshenziswa kwezidakamizwa ezithile, isibonelo, i-insulin, i-amphetamine noma amalungiselelo e-lithium.
Uma i-ACTH iyancishiswa
I-hormone ye-Adrenocorticotropic iyancipha kulezi zifo ezilandelayo:
- umsebenzi we-pituitary wehlile;
- umsebenzi wehlile we-cortex eyingozi;
- uma kunezinhlayiya zezinhlayiya ze-adrenal;
- ne-hormonal therapy, lapho iziguli zithatha i-glucocorticoids;
- izifo ze-bronchial and lung.
Kumele kuqashelwe ukuthi udokotela angakhipha ukuhlaziywa kwamazinga we-serum we-ACTH uma izimpawu ezilandelayo zigcinwa:
- ukhathala okwandayo;
- ukucindezeleka ukumelana;
- i-syndrome engapheliyo;
- umfutho wegazi ophezulu.
Futhi, kwenziwa isifundo esifanayo ukuqapha isimo somzimba lapho ukwelapha izidakamizwa ze-hormone.
Unganaki ukuqokwa kukadokotela ukuze uhlaziye izinga le-ACTH. Ngokomphumela walo, ungafaka ukuxilongwa okufanele ngesikhathi futhi uqale ukwelashwa okwanele.