Leli klasi lezifo zabantu, njenge-autoimmune, lihlotshaniswa nemisebenzi ye-immune system engakhubazekile kanye nokukhiqizwa kwamagciwane okulwa nomzimba okusebenza ngokumelene nezicubu zomzimba ezinempilo futhi kuholela ekuguqulweni kwabo noma ekubhujisweni kwabo. Lezi zifo zingathinta izitho ezihlukahlukene nezinhlelo, kubandakanya isibindi. Ngakho-ke, kubantu besifazane, ikakhulukazi eneminyaka engama-40-50 ubudala, i-cirrhosis eyinhloko ye-biyary cirrhosis ingakhula, futhi ezimweni eziningi umlingiswa womndeni wesifo uyabonakala (phakathi kwamadade, omama namadodakazi, njll).
Izimbangela nezigaba ze-cirrhosis eyinhloko ye-biliary
Okwamanje, aziwa ukuthi yiyiphi indlela yokuqala yokuthuthukiswa kwe-cirrhosis eyinhloko ye-biliary, kulezi zifundo zenkinga nezingxoxo ziyaqhubeka. Phakathi kokucabangela ngezimbangela zezinkinga kukhona okulandelayo:
- ukutheleleka kwegciwane kanye nebhaktheriya (amaconyo amuva nje ngesimo esithathelwanayo sesifo aphakanyiswa kakhulu);
- ukuphazamiseka kwe-hormonal;
- izici zofuzo;
- umthelela emzimbeni wamakhemikhali;
- ezinye izifo ezizimele (isifo samathambo, isifo sikaRaynaud, i-Sjogren's syndrome, i-autoimmune thyroiditis, i-scleroderma, i-tubular renal acidosis, njll).
Kunezigaba ezine ekuthuthukiseni lesi sifo:
- Esikhathini sokuqala, ngenxa yokuphendula okuzenzakalelayo, ukuvuvukala okungenakuvuvukala okuvuvukala kwe-intrahepatic bile-ducts kwenzeka, kubonakala ukuthi i-bile stagnation ibonakala.
- Khona-ke kuncipha kwinombolo ye-bile ducts, ukuvinjwa kwe-excretion ye-bile nokungena kwayo egazini.
- Amapheshana e-portal ashintshwe ngezicubu ezibomvu, izibonakaliso zokuvuvukala okusebenzayo kanye nezimo eziphathelene necrotic kule parenchyma ziyabonakala.
- Isiteji se-cirrhosis encane-ne-coarse-nodular enezibonakaliso ze-cholestasis ye-peripheral nephakathi.
Izimpawu ze-cirrhosis eyinhloko ye-biliary
Ukubonakaliswa kokuqala kwe-pathology, lapho iziguli ezivame ukukhononda ngazo, ziyizi:
- ubuthakathaka obunzima, ukukhathala okusheshayo, ukulala okukhulu, ukunciphisa kakhulu umsebenzi nokunciphisa ikhono lokusebenza;
- ukuhlunga isikhumba (ezimweni eziningi kubonakala, kubi kakhulu ebusuku, futhi emva kokugeza, ukuthinta imikhiqizo yobisi);
- ukuqina kwesikhumba, ukuqinisa iphethini lesikhumba;
- i-icterus yesikhumba, i-membrane yamangqamuzana, i-sclera;
- amehlo omile ;
- ukungathandeki, isisa ku-hypochondrium efanele.
Futhi, iziguli zivame ukuphazamiseka ukunyuka okuncane kokushisa komzimba, ukuphathwa ikhanda, ukungabi nesifiso sokudla, ukulahlekelwa isisindo, isimo sokucindezeleka. Kwezinye iziguli, i-cirrhosis eyinhloko ye-biliary esigabeni sokuqala sesinxephezelo cishe ayifaneleki.
Khona-ke lezi zimpawu ezilandelayo zengeziwe kumpawu ezibalwe:
- Amahlumela ase-Vascular esikhumbeni;
- ubomvu obusweni, izinyawo nezindwangu;
- ukuchithwa kwezipikili ("ingilazi yokubukela"), ukubonakala kwamabhande amhlophe aguqukayo;
- ukuqina kwe-nail phalanges.
Ngenxa yokuphazamiseka kokumunwa kwamavithamini nezinye izakhi, i-osteoporosis, i-steatorrhea, i-hypothyroidism, i-varicose veins yemithanjeni ye-hemorrhoid ne-esophageal, i-ascites, ukuphuma kwegazi kanye nezinye izinkinga zingase zakhiwe.
Ukuxilongwa kwe-cirrhosis eyinhloko ye-biliary
Ukulethwa kwalesi sifo kutholakala ekuhlolweni kwelabhorethri:
- ukuhlolwa kwegazi jikelele;
- ukuhlola igazi kwegazi ;
- i-coagulogram;
- izivivinyo ze-hepatic;
- i-lipidogram;
- ukuhlaziywa okujwayelekile komchamo.
Qinisekisa ukuthi ukuxilongwa kungenzeka nge-biopsy yesibindi, eyenziwa ngaphansi kokulawulwa kwe-ultrasound.
Ukwelashwa kwe-cirrhosis eyinhloko ye-biliary
Ukwelashwa okuqondile kwalesi sifo akukhona, kuphela izindlela ezinciphisa ubukhulu bezimpawu zomtholampilo, zimise ukuqhubekela phambili kwe-cirrhosis, ukuvimbela ukuthuthukiswa kwezimo ezinzima. Ngokuyinhloko, lezi zinhlelo zemithi ngokuqokwa kwezidakamizwa zokuzivikela, i-glucocorticosteroids, i-cholagogues, i-hepatoprotectors, i-antihistamine, njll. Izindlela ze-physiotherapeutic nazo zisetshenziselwa ukudla okukhethekile. Ezimweni ezinzima, ukungenelela okuhlinzekwayo okuhlinzekwa ngokuhlinzwa kuqhutshwa kuze kufike ekufakweni kwesibindi.