I-Clavulanic acid iyisici esikhethekile esithinta ngokuqinile ne-penicillinase futhi ayisebenzise. Kungabonakala ekubunjweni kwezidakamizwa ezinamandla kakhulu ezihlangene. Ngaphezu kwalokho, i-clavulanic acid ingasetshenziswa ngokufanayo namagciwane we-beta-lactam.
Indlela yokwenziwa kwe-clavulanic acid
Ochwepheshe bathi i-clavulanic acid i-metabolism. Lesi sici sikwazi ukukhiqiza umphumela onamandla we-antimicrobial. Izidakamizwa eziqukethe i-clavulanic acid zikhonjiswe ukuze zisetshenziswe ngezifo ezihlukahlukene zokuvuvukala ezibangelwa amagciwane anobungozi namagciwane.
Ukwakhiwa kwama-molecule we-clavulanic acid kufana nemithi elwa ne-antibiotics yochungechunge lwe-penicillin. Yingakho inhlanganisela yabo kusukela ekubukeni kwezemithi kubhekwa ngokuphumelelayo. Umehluko omkhulu ukuthi i-asidi esikhundleni se-thiazolidine kukhona indandatho ye-oxazolidine. Kodwa ukuhambisana kwezinto akuthinteki neze.
Ukungena emzimbeni, i-clavulanic acid ivimbela i-beta-lactamase - ama-enzyme ebhaktheriya, okubonakala okwenza umsebenzi obalulekile wezincane ezincane eziyingozi. Ngokuvamile, isimiso sesenzo se-clavulanic acid silula: ngegobolondo elivikelayo, lingene emangqamuzaneni amabhaktheriya bese "liguqula" ama-enzyme angaphakathi. Ngakho-ke, le nto ayivumeli ukuthi amagciwane namabhaktheriya aphindwe.
Njengoba umkhuba ubonisiwe, ngemva kokunciphisa, ukunciphisa kwe-beta-lactamase kubhekwa kungenakwenzeka. Ngenxa yalezi zinambuzane ezincane ze-pathogenic azikwazi nje ukuthuthukisa, kodwa futhi zilahlekelwa ithuba lokuthuthukisa ukumelana nemithi elwa namagciwane okubacindezela.
Ukusebenza kwezinto ezibonakalayo kuphakeme kakhulu. Ngisho nalawo maqabunga amabhaktheriya namagciwane akwazi ukuthuthukisa ukuzivikela ngokumelene ne-Amoxicillin ne-Ampicillin abhujiswe yisenzo se-clavulanic acid. Okusho ukuthi isenzo esiningi semithi ehlanganisiwe siningi kakhulu kunezokwelapha ezivamile.
Ngokuyinhloko, izidakamizwa nge-clavulinic acid zithathwa ngomlomo, kodwa kwezinye izimo, ukuphathwa kwabo okubambisana kubhekwa njengokusebenza kahle. Ngenxa yalokho, azikho ukuphikisana komuthi, akufanele kuphela iziguli ezinokungaboni ngaso sonke isikhathi. Ezimweni ezinzima kakhulu, i-clavulic acid ehlangene ne-Amoxicillin ne-Ticarcillin ingathathwa ngisho nabesifazane abakhulelwe.
Augmentin - Amoxicillin nge-clavulanic acid
Lena enye yama-antibiotic ehlanganiswa kakhulu. Isidakamizwa siboniswa ngezifo ezinjalo:
- i-bronchitis (kufaka phakathi ifomu elingavamile);
- i-pneumonia;
- i-abscess yamaphaphu ;
- ukutheleleka kwebhaktheriya;
- i-cystitis;
- i-peritonitis;
- i-osteomyelitis;
- i-angina;
- i-septicemia;
- i-pyelonephritis.
Isilinganiso se-Augmentin sesiguli ngasinye sikhethwe ngabanye, kuye ngokuthi ifomu nesimo esiyinkimbinkimbi yesifo, isimo esiphelele sesiguli, ubudala sakhe, ukuxilongwa okuhambisanayo. Ukwelashwa ngesidakamizwa kufanele kudlule isikhathi esingaphansi kwezinhlanu, kodwa hhayi okungaphezu kwezinsuku eziyishumi nane.
I-Flemoxin ene-clavulanic acid
Lena enye inhlanganisela eyaziwa kakhulu, ebizwa ngokuthi iFlemoklav. I-antibacterial agent enhle idlula kancane kune-Flemoxin yasekuqaleni, kodwa inani layo lilungele ngokugcwele ukusebenza kwalo.
Ithuluzi lisetshenziselwa ukuphatha izinqubo ezihlukahlukene zokuvuvukala:
- i-otitis media;
- i-pharyngitis ;
- i-bronchitis;
- i-pneumonia etholakale emphakathini;
- ukutheleleka kwesisu;
- ukuvuvukala kwe-dermatological;
- izilonda ezithathelwanayo nezivuthayo zamathambo namalunga.
I-Flemoklav idedelwa ngendlela yamaphilisi ahlanganisiwe, ngenxa yokuthi ukuphumelela kwayo kuphakama ngisho nangaphezulu.